Endocrine Abstracts

Many marine sponges have been shown to produce metabolites with cell growth and endocrine altering activities. We tested crude extracts (1.0 mg/ml) from two species (AV and SB) for effects on levels of an important cell cycle regulatory protein, cyclin B1; cell cycle growth-phase (sub-G1/Apoptosis, G1, S, and G2/M), as well as on cell survival in SW-13 human adrenal carcinoma cultures. Polyacrylamide gel electrophoresis studies of cyclin B1 levels indicate a 60-90 % reduction ...

Ovarian cancer is the leading cause of death from all gynaecological malignancies. The observation that decreased levels of the natural oestrogen-17beta metabolite, 2-methoxyoestradiol (2-MeOE2) may create a predisposition to oestrogen dependent cancer, has led to considerable interest in the potential use of oestrogen derivatives for the prevention and treatment of hormone dependent cancers. The sulphamoylated oestrone derivative 2-methoxyoestrone-3-O-sulphamate (2-MeO...